How CBD Works in Dogs
The Endocannabinoid system in dogs is part of what maintains the natural balance in the body and it is usually stimulated by endocannabinoids (which are produced internally). However, the endocannabinoid system can also be stimulated by external cannabinoids, including Cannabidiol (CBD) – the non-phsycoactive compound found in industrial hemp.
Cannabinoid CB1 & CB2 Receptor Locations in Dogs
The Endocannabinoid System (ECS) is a group of endogenous cannabinoid receptors that are located throughout the body. It has two kinds of receptors: CB1 & CB2.
CB1 receptors are mostly in the brain and central nervous system.
CB2 receptors are mostly in peripheral organs, especially immune cells.
CB1 & CB2 |
CB1 |
CB2 |
| Immune system Liver Bone marrow Pancreas Brainstem |
Brain Lungs Vascular system Muscles Gastrointestinal tract Reproductive organs |
Spleen Bones Skin Glial cells (parts of the brain) |
Cannabinoid Receptor Locations in the Brain
Cerebral Cortex |
Hypothalamus |
| Plays a role in memory, thinking, awareness and consciousness | Governs metabolic processes such as appetite |
Amygdala |
Hippocampus |
| Plays a role in emotions | Is key to memory storage and recall |
Basal Ganglia |
Cerebellum |
| Governs motor skills and learning | Governs coordination and muscle control |
Brain Stem |
| Controls many basic functions including vomiting reflex, blood pressure and heart rate. Also plays a role in pain sensation, muscle tone, and movement |